大发快三高手计划

    

陈晔光 博士

教授、中科院院士、国家杰出青年基金获得者、长江学者特聘教授


1979-1983 江西大学生物系,生物学学士
1983-1986 江西大学生物系,动物学硕士
1988-1990 美国福特汉姆大学,细胞生物学硕士
1991-1996 美国爱因斯坦医大发快三高手计划,细胞生物学博士
1996-2000 美国霍华德·休斯大发快三高手计划研究所斯隆-凯特琳癌症中心,博士后
2000-2002 美国加州大学Riverside分校,Assistant Professor
2002-至今 清华大学生命科学大发快三高手计划,教授、博导

●  研究兴趣、领域:


探究TGF-β和Wnt信号调控细胞命运的分子机制和生理病理功能; 运用分子生物学、细胞生物学、生物信息学等多学科技术手段,结合类器官技术和小鼠模型等,研究肠、胃等成体干细胞自我更新和分化的机制,并探索相关疾病发生发展的机理。

●  开设的课程:


《细胞生物学》、《肿瘤生物学专题讨论》

●  代表性论文:


 

  1. Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG#. (2021) Phase separation of Axin organizes the β-catenin destruction complex.  Journal of Cell Biology, In press.

  2. Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#,  Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2).

  3. Li YZ, Liu Y, Y. J Chiang, Huang F, Li YH, Li XT,Ning YH, Zhang WH, Deng HT, Chen YG#. (2019) DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TbRII.  Cell Reports, 28(3):735.

  4. Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#.  (2018) HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073.

  5. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.  Nature Communications, 8:13824.

  6. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG#. (2015) Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis.  Nature Communications, 6:7166.

  7. Ma BY, Cao WP, Li WX, Gao C, Qi Z, Zhao Y, Du J,  Xue H, Peng JY, Wen J,  Chen H, Ning YH,  Huang L, Zhang H, Gao X, Yu L, Chen YG# . (2014) Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. Cell Research,  24(8):912.

  8. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#. (2013) c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499.

  9. Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG#. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22(10):1467.

  10. Li, Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#. (2012) BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171.

  11. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han J#, Chen YG#. (2010) Genome-wide Mapping of SMAD Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research  20(1):36.

  12. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#.(2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.  Nature Cell Biology,12(8):781.

  13. Zhang W, Jiang YX, Wang Q, Ma XY, Xiao ZY, Zuo W, Fang XH#, Chen YG#.  (2009) Single-molecule imaging reveals TGF-β induced type II receptor dimerization. Proceedings of the National Academy of Sciences, USA  106:15679.

  14. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG#. (2008) MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588.

  15. Ma J, Wang Q, Fei T, Han JD, Chen YG#.  (2007) MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987.

  16. Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG#. (2006)  Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia.  Blood, 107:1951.

  17. Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A#. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114.

 

●  荣誉、奖励及参加学术团体的情况:


现任中国细胞生物学会理事长、Cell Regeneration杂志主编以及Cell Research、Cell Discovery、Open Biology、Journal of Cellular and Molecular Medicine、International Journal of Biochemistry and Cell Biology、Journal of Experimental & Clinical Cancer Research、Experimental Cell Research、Cancer Sciences和《中国科学:生命科学》等期刊编委。

●  联系方式:


电话:010-62784794

E-mail:ygchen@tsinghua.edu.cn

Websites: