大发快三高手计划

   

姚骏 博士

研究员,博导


1999, 南京大学生物科学与技术系   学士

2001, 南京大学生物科学与技术系   硕士

2007, 美国宾夕法尼亚州立大学       博士

2007-2011      美国霍华德休斯大发快三高手计划研究所,威斯康星大学      Postdoctoral Research Associate

2011-2013      美国萨克生物学研究所                                       Research Associate

2013-              清华大学生命科学大发快三高手计划                                       研究员

 

●  研究兴趣、领域:


课题组致力于从遗传学、分子和神经环路等多个维度阐明情感障碍(双相情感障碍和抑郁症)的发病机理。情感障碍是发病率、遗传率和自杀率最高的一类疾病,但目前这类疾病的发病机理仍不清楚,临床药物也存在很多限制和副作用。课题组的研究主要基于多能干细胞(iPSC)、3D类脑和小鼠模型,采用膜片钳和在体电生理、超高分辨率显微成像、动物行为学、光遗传、冷冻电镜以及多种基因测序手段,从病人iPSC分化的神经元和3D类脑中遴选出疑似与发病相关的关键基因或分子通路,结合类脑和小鼠模型,探究:1)该通路导致疾病发生的分子水平机理;2)其产生致病影响的小鼠关键脑区和神经环路;3)在人类神经元中受不同易感基因调控的遗传学机制。

 

 

●  代表性论文:


1. Lu SY, Fu CL, Liang L, Yang B, Shen W, Wang QW, Chen Y, Chen YF, Liu YN, Zhu L, Zhao J, Shi W, Mi S, Yao J. miR-218-2 regulates cognitive functions in the hippocampus through C3-dependent modulation of synaptic vesicle release. Proc Natl Acad Sci U S A. 2021 Feb. (in press)
2. Chen Y, Wang YH, Zheng Y, Li M, Wang B, Wang QW, Fu CL, Liu YN, Li X, Yao J. Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons. Cell Reports. 2021 Feb. (in press)
3. Wang QW, Lu SY, Liu YN, Chen Y, Wei H, Shen W, Chen YF, Fu CL, Wang YH, Dai A, Huang X, Gage FH, Xu Q, Yao J. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 Nov 23:202016416. doi: 10.1073/pnas.2016416117.
4. Shen W, Wang QW, Liu YN, et al., Gage FH, and Yao J. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4392-4399. doi: 10.1073/pnas.1918165117. Epub 2020 Feb 10.
5. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, and Yao J. CRISPR interference-based specific and efficient gene inactivation in the brain. Nature Neuroscience. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5.
6. Liu, Y.N., Lu, S.Y., and Yao, J. (2017). Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia. Psychiatry Clin Neurosci. 2017 Apr 10. doi: 10.1111/pcn.12528. [Epub ahead of print]
7. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, ?degaard KJ, McCarthy MJ, Zandi PP, PBDS, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature. 2015 Nov 5;527(7576):95-9. doi: 10.1038/nature15526. Epub 2015 Oct 28.  

 

 

●  联系方式:


电话:+86-10-62797147(办公室);

Email: jyao@mail.tsinghua.edu.cn

实验室主页:http://yaolab.life.tsinghua.edu.cn